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Phenotypes Associated with This Genotype
Genotype
MGI:3785750
Allelic
Composition
Ddr2slie/Ddr2slie
Genetic
Background
BKSChpLt.Cg-Tg(Ins2-Cpe)1Lt Cpefat/LtJng
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ddr2slie mutation (1 available); any Ddr2 mutation (4 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• 15% of homozygotes die before 3 months of age and 47% die by 6 months (J:134371)
• 15% of homozygotes die before 3 months of age and 47% die by 6 months (J:134371)

endocrine/exocrine glands
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood (J:134371)
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood (J:134371)
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)

growth/size/body
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype (J:134371)
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype (J:134371)
• snub nose is visible by four months of age (J:134371)
• snub nose is visible by four months of age (J:134371)
• significant increase in percentage of lean mass at 5-6 months as compared to wildtype (J:134371)
• significant increase in percentage of lean mass at 5-6 months as compared to wildtype (J:134371)
• after weaning weight gain is slower than wildtype (J:134371)
• homozygotes do not exhibit juvenile growth spurt (J:134371)
• after weaning weight gain is slower than wildtype (J:134371)
• homozygotes do not exhibit juvenile growth spurt (J:134371)

adipose tissue
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype (J:134371)
• significant decrease in percentage of body fat at 5-6 months as compared to wildtype (J:134371)

craniofacial
• snub nose is visible by four months of age (J:134371)
• snub nose is visible by four months of age (J:134371)

homeostasis/metabolism
• following injection of exogenous gonadotropin in 12-14 week old mice, testosterone levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, testosterone levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, estradiol levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, estradiol levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, progesterone levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, progesterone levels are lower than adult wildtype and similar to prepubertal wildtype (J:134371)

vision/eye
• protuberant eyes are observed by four months of age (J:134371)
• protuberant eyes are observed by four months of age (J:134371)

skeleton
• bone mineral content is reduced in comparison to wildtype, however density is not reduced (J:134371)
• bone mineral content is reduced in comparison to wildtype, however density is not reduced (J:134371)

reproductive system
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)
• corpora lutea is absent in 6 week old and 4 month old females, however, pre-antral, antral and Graffian follicles appear normal (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, vaginal opening is observed in 100% of prepubertal wildtype and 80% of adult homozygotes, however, the condition is pre-existing in wildtype 12-14 week old mice (J:134371)
• following injection of exogenous gonadotropin in 12-14 week old mice, vaginal opening is observed in 100% of prepubertal wildtype and 80% of adult homozygotes, however, the condition is pre-existing in wildtype 12-14 week old mice (J:134371)
• number of spermatids is reduced in 4 month old mice, but not in 6 week old mice (J:134371)
• number of spermatids is reduced in 4 month old mice, but not in 6 week old mice (J:134371)
• females are anovulatory (J:134371)
• following injection of PMSG and hCG at 6 weeks follicular growth to the Graffian stage is induced, but, full luteinization of thecal cells does not occur (J:134371)
• females are anovulatory (J:134371)
• following injection of PMSG and hCG at 6 weeks follicular growth to the Graffian stage is induced, but, full luteinization of thecal cells does not occur (J:134371)
• female homozygote matings to wildtype fail to produce offspring (J:134371)
• female homozygote matings to wildtype fail to produce offspring (J:134371)
• occasionally homozygote males crossed to heterozygote or wildtype females produce offspring (J:134371)
• occasionally homozygote males crossed to heterozygote or wildtype females produce offspring (J:134371)

nervous system
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood (J:134371)
• proportion of pituitary gland area to whole brain area is reduced as compared to wildtype at 4 weeks, however, size difference disappears by adulthood (J:134371)

cellular
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)
• atrophy is observed in spermatogonia, Leydig and Serotoli cells at 4 months (J:134371)

Mouse Models of Human Disease
OMIM ID Ref(s)
Dwarfism, Levi Type 127100 J:134371


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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory