About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3785390
Allelic
Composition
Tg(Thy1-SOD1*G93A)T3Hgrd/Tg(Thy1-SOD1*G93A)T3Hgrd
Genetic
Background
involves: C57BL/6 * CBA * FVB
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Thy1-SOD1*G93A)T3Hgrd mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
growth/size/body
• at end-stage, most mice display severe weight loss (>30%) (J:134095)
• at end-stage, most mice display severe weight loss (>30%) (J:134095)

nervous system
• accumulation of argyrophilic neuronal debris is seen throughout medullary, pontine, and mesencephalic reticular formation up to zona incerta (J:134095)
• accumulation of argyrophilic neuronal debris is seen throughout medullary, pontine, and mesencephalic reticular formation up to zona incerta (J:134095)
• signs of reactive gliosis are seen at disease end-stage (J:134095)
• signs of reactive gliosis are seen at disease end-stage (J:134095)
• animals not displaying motor abnormalities show ubiquinated neurites in spinal cord (J:134095)
• animals not displaying motor abnormalities show ubiquinated neurites in spinal cord (J:134095)
• in mice at end-stage, denervation is observed at neuromuscular synapses (J:134095)
• in mice at end-stage, denervation is observed at neuromuscular synapses (J:134095)
• appears restricted to brainstem and spinal cord (J:134095)
• appears restricted to brainstem and spinal cord (J:134095)
• accumulation of argyrophilic neuronal debris is seen in spinal cord of mice at end-stage of disease; similar amounts are seen between left and right, and lumbar and cervical segments (J:134095)
• accumulation of argyrophilic neuronal debris is seen in spinal cord of mice at end-stage of disease; similar amounts are seen between left and right, and lumbar and cervical segments (J:134095)
• loss of motor neurons is detected at disease end-stage (J:134095)
• loss of motor neurons is detected at disease end-stage (J:134095)

behavior/neurological
• at end-stage, severe locomotor deficits are exhibited (J:134095)
• at end-stage, severe locomotor deficits are exhibited (J:134095)
• at end-stage, loss of ability to hang in hanging wire test (J:134095)
• at end-stage, loss of ability to hang in hanging wire test (J:134095)
• loss of grip strength at end-stage of disease (J:134095)
• loss of grip strength at end-stage of disease (J:134095)

muscle
• exhibited by most mice (60%) before 2 years of age; onset is observed at 378 to >730 days with end stage reached at >432 to >730 days (J:134095)
• exhibited by most mice (60%) before 2 years of age; onset is observed at 378 to >730 days with end stage reached at >432 to >730 days (J:134095)

cellular
N
• mice do not develop mitochondrial swelling and vacuolization like G1 or G1del mutants (J:134095)
• mice do not develop mitochondrial swelling and vacuolization like G1 or G1del mutants (J:134095)

Mouse Models of Human Disease
OMIM ID Ref(s)
Amyotrophic Lateral Sclerosis 1; ALS1 105400 J:134095


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
Citing These Resources
Funding Information
Warranty Disclaimer & Copyright Notice
Send questions and comments to User Support.
last database update
01/26/2016
MGI 6.02
The Jackson Laboratory