Analysis Tools
behavior/neurological
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• 16 month old mutant mice exhibit increased freezing time during initial testing and 24 hours later as compared to age-matched wild-type mice
• 4 month old mutant mice exhibit increased freezing time during training, but not retention
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• age-matched 16 month old mutant mice more quickly relearn and retain new platform location than wild-type mice is reversal trial of water T maze
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• age-matched 16 month old mutant mice more quickly relearn and retain new platform location than wild-type mice is reversal trial of water T maze
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• 16 month old mutant mice spend more ambulatory time in the center of the field than age-matched wild-type mice
• 16 month old mutant mice make more total open arm entries than age-matched wild-type mice
• 16 month old mutant mice make more contacts with novel objects in first minute of test than age-matched wild-type mice
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immune system
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• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic IgM or IgA self-antibodies
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• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice
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• following exposure to LPS then challenge with TNF at the same site to initiate a local Shwartman response, mice fail to exhibit hemorrhage and exhibit reduced fibrin deposition compared to the thrombohemorrhagic vasculitis observed in wild-type mice despite normal neutrophil accumulation
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• reduced granulocyte infiltration of infarct sites
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homeostasis/metabolism
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• mouse serum fails to support neutrophil adhesion unlike serum from wild-type mice
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• significantly reduced infarct volume but mortality unaffected
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hematopoietic system
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• mice are resistant to hemolytic anemia induced by self-binding IgG2a antibodies
• no protection is seen with pathogenic IgM or IgA self-antibodies
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• neutrophils that accumulate at the site of a local Shwartman response are round instead of flattened as in wild-type mice
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nervous system
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• synaptic puncta density in the hippocampal CA3 region is higher in mutant males than in wild-type males at 4 months of age;
density is similar to wild-type at P30
• protective effects (to a lesser extent) against synapse loss are also observed in hippocampal DG and V1 regions, but not in the CA1 region, at 16 months of age
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• significantly reduced infarct volume but mortality unaffected
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• reduced granulocyte infiltration of infarct sites
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• mutant mice do not exhibit age-dependent neuron loss in the hippocampal CA3 region from P30 to 16 months
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• increased dendritic spine density is observed in the hippocampal CA3 region of 16 month old mice as compared to wild-type
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• mutant mice do not exhibit age-dependent neuron loss in the hippocampal CA3 region from P30 to 16 months
• neuron numbers in CA1, V1 cortex and cerebellum are similar to wild-type
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• synaptic plasticity is improved as compared to age matched 12 month old wild-type mice
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• observed in 12 month old mice as compared to age-matched wild-type
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• observed in 12 month old mice as compared to age-matched wild-type
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reproductive system
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• 5.42 days vs 4.41 days in controls
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• insignificantly but consistently reduced level of implantation at day 8
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embryo
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• blastocyst count at 4 days is consistently but insignificantly lower than in controls
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• significantly reduced spongioblast at day 15 of pregnancy
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• labyrinth area significantly reduced at day 15 of pregnancy
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• reduced placenta area at day 15 of pregnancy
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growth/size/body
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• significantly reduced fetal weight
• reduced fetus/placenta ratio
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cellular
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• synaptic puncta density in the hippocampal CA3 region is higher in mutant males than in wild-type males at 4 months of age;
density is similar to wild-type at P30
• protective effects (to a lesser extent) against synapse loss are also observed in hippocampal DG and V1 regions, but not in the CA1 region, at 16 months of age
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