Phenotypes Associated with This Genotype

Genotype
MGI:3785167

• Allelic Composition: Chrm1^tm1Stl/Chrm1^tm1Stl
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal excitatory postsynaptic potential ( J:112782 )

• mice exhibit a greater increase in excitatory postsynaptic potential amplitude following treatment with MCN-A-343, a selective Chrm1 inhibitor, compared to in wild-type mice

• however, responses to GABAB and Chrm1 antagonist are normal

reduced long-term depression ( J:112782 )

• long term depression of field excitatory postsynaptic potential induced by muscarine treatment is reduced compared to in similarly treated wild-type mice

decreased paired-pulse facilitation ( J:112782 )

• when treated with muscarine