Phenotypes Associated with This Genotype

Genotype
MGI:3785086

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Lipg^tm1Tq/Lipg^tm1Tq
• Genetic Background: involves: 129P2/OlaHsd * 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

increased circulating cholesterol level ( J:93987 )

• when fed a high fat diet, male mice exhibit a 2-fold increase in serum cholesterol compared to in either single homozygote on either a normal or high fat diet

increased circulating HDL cholesterol level ( J:93987 )

• compared to in Apoe^tm1Unc homozygotes

increased circulating LDL cholesterol level ( J:93987 )

• compared to in wild-type mice

increased circulating VLDL cholesterol level ( J:93987 )

• compared to in wild-type mice

increased circulating phospholipid level ( J:93987 )

increased circulating triglyceride level ( J:93987 )

• in male mice on a high fat diet

cardiovascular system

decreased susceptibility to atherosclerosis ( J:93987 )

• formation of atherosclerotic plaques is attenuated compared to in Apoe^tm1Unc homozygotes

• when fed a normal diet, atherosclerotic lesions are 67% smaller in females and 71% smaller in males compared to in Apoe^tm1Unc homozygotes

• when fed a high fat diet, atherosclerotic lesion formation is attenuated in male mice and lesion size is decreased 24% compared to in Apoe^tm1Unc homozygotes

atherosclerotic lesions ( J:93987 )

• atherosclerotic lesions contain fewer macrophage infiltration than in Apoe^tm1Unc homozygotes

• monocyte/macrophage binding to atherosclerotic lesions in vitro is reduced compared to in Apoe^tm1Unc homozygotes