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Phenotypes Associated with This Genotype
Genotype
MGI:3785080
Allelic
Composition
Ighmbp2nmd-2J/Ighmbp2nmd-2J
Tg(Ttn-Ighmbp2)45Cx/?
Genetic
Background
involves: C57BL/6J * C57BLKS/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ighmbp2nmd-2J mutation (5 available); any Ighmbp2 mutation (46 available)
Tg(Ttn-Ighmbp2)45Cx mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
• lifespan is longer than that of nmd-2J mutants but shorter than that of the wild-type controls and falls partway between the two points

nervous system
• severe skeletal muscle neurogenic atrophy

muscle
• resulting from the spinal motor neuron degeneration

behavior/neurological
• difficulty in mastication or deglutition

cardiovascular system
N
• mean ventricular free-wall thickness is normal

digestive/alimentary system
• difficulty in mastication or deglutition
• susceptible to mega-esophagus

growth/size/body
• susceptible to mega-esophagus
• the presence of the transgene does not rescue the weight loss found in nmd-2J homozygotes


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory