homeostasis/metabolism
• mice fail to exhibit a vasodilation, altered blood pressure or increased synovial joint swelling in response to ASKH95 unlike wild-type mice
• acute inflammatory responses to carageenan/kaolin is reduced compared to in heterozygous (26% decrease) and wild-type mice (40% decrease)
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• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice
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nervous system
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice
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immune system
• chronic joint inflammation is inhibited in mutants
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skeleton
• chronic joint inflammation is inhibited in mutants
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