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Phenotypes Associated with This Genotype
Genotype
MGI:3784945
Allelic
Composition
F2rl1tm1Wrf/F2rl1tm1Wrf
Genetic
Background
involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Wrf mutation (0 available); any F2rl1 mutation (60 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
homeostasis/metabolism
• mice fail to exhibit a vasodilation, altered blood pressure or increased synovial joint swelling in response to ASKH95 unlike wild-type mice
• acute inflammatory responses to carageenan/kaolin is reduced compared to in heterozygous (26% decrease) and wild-type mice (40% decrease)
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

nervous system
• following middle cerebral artery occlusion, infarct size and number of TUNEL-positive cells was increased compared to in wild-type mice

immune system
• chronic joint inflammation is inhibited in mutants

skeleton
• chronic joint inflammation is inhibited in mutants


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/25/2025
MGI 6.24
The Jackson Laboratory