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Phenotypes Associated with This Genotype
Genotype
MGI:3784877
Allelic
Composition		 F2rl1tm1Cgh/F2rl1tm1Cgh
Genetic
Background		 B6.129S4-F2rl1tm1Cgh
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
F2rl1tm1Cgh mutation (3 available); any F2rl1 mutation (60 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased dendritic cell number ( J:113591 )
• mice fail to develop bone marrow-derived dendritic cells with to without soy bean trypsin inhibitor treatment unlike wild-type mice
• however, stimulation with TNG-alpha or by crosslinking CD40 results in mature dendritic cell development

hematopoietic system
decreased dendritic cell number ( J:113591 )
• mice fail to develop bone marrow-derived dendritic cells with to without soy bean trypsin inhibitor treatment unlike wild-type mice
• however, stimulation with TNG-alpha or by crosslinking CD40 results in mature dendritic cell development

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory