Phenotypes Associated with This Genotype

Genotype
MGI:3784874

• Allelic Composition: F2r^tm1Ajc/F2r^tm1Ajc; F2rl1^tm1Cgh/F2rl1^tm1Cgh
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

increased susceptibility to induced morbidity/mortality ( J:132733 )

• female mice exhibit a decreased survival following exposure to endotoxin compared to wild-type mice

decreased survivor rate ( J:132733 )

• only 5 % of expected mice are born and survive into adulthood to reproduce

embryonic lethality, incomplete penetrance ( J:132733 )

• only 5% of expected mice were born

• however, surviving mice survive into adulthood

immune system

increased susceptibility to endotoxin shock ( J:132733 )

• female mice exhibit a decreased survival following exposure to endotoxin compared to wild-type mice and produce more cytokines at low doses of endotoxin