Phenotypes Associated with This Genotype

Genotype
MGI:3784868

• Allelic Composition: Gt(ROSA)26Sor^tm1(ptxA)Cgh/Gt(ROSA)26Sor⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:130781 )

• unlike in wild-type mice, glucose and insulin levels are unresponsive to treatment with 3-iodothyronamine

hypoglycemia ( J:130781 )

increased circulating insulin level ( J:130781 )

• plasma insulin levels are 4- to 5-fold higher than in wild-type mice

• plasma insulin levels following administration of glucose increased 6.5-fold over basal levels compared to an increase of only 3-fold in similarly treated wild-type mice and peak insulin level achieved is 15-fold higher than in similarly treated wild-type mice

improved glucose tolerance ( J:130781 )

• glucose clearance is increased compared to in wild-type mice

• when fed a high fat diet, mice exhibit improved glucose tolerance and normal fasting blood glucose levels compared to wild-type mice

• unlike wild-type mice, treatment with SLIGRL does not alter plasma glucose levels

endocrine/exocrine glands

endocrine/exocrine gland phenotype ( J:130781 )

N • despite altered glucose homeostasis, mice exhibit normal pancreatic islet cell size, number, histological appearance and cellular composition