Analysis Tools
immune system
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• mice exhibit a normal response to endotoxin treatment
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• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
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• mice exhibit a resistance to antibody-induced crescentic glomerulonephritis with reduced crescent formation, protenuria, glomerular fibrin deposition, and serum creatinine compared to wild-type mice 21 days after induction
• however, following induction of crescentic glomerulonephritis, nephritogenic antiboe production, NO generation, inflammatory response and glomerular cell proliferation are normal
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liver/biliary system
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• the gallbladder fails to exhibit a normal short-circuit current response when stimulated with TFLLRN-NH2 and thrombin
• however, the short-circuit response to SLIGRL-NH2 and trypsin is normal
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homeostasis/metabolism
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• treatment with SLIGRL leads to a 20% drop in plasma insulin levels compared to greater than 50% drop in wild-type mice and plasma glucose levels fail to increase unlike in similarly treated wild-type mice
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• mice exhibit a resistance to antibody-induced crescentic glomerulonephritis with reduced crescent formation, protenuria, glomerular fibrin deposition, and serum creatinine compared to wild-type mice 21 days after induction
• however, following induction of crescentic glomerulonephritis, nephritogenic antiboe production, NO generation, inflammatory response and glomerular cell proliferation are normal
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renal/urinary system
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• mice exhibit a resistance to antibody-induced crescentic glomerulonephritis with reduced crescent formation, protenuria, glomerular fibrin deposition, and serum creatinine compared to wild-type mice 21 days after induction
• however, following induction of crescentic glomerulonephritis, nephritogenic antiboe production, NO generation, inflammatory response and glomerular cell proliferation are normal
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cellular
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• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
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hematopoietic system
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• following surgical trauma, mean leukocyte rolling flux fraction at 0 to 15 minutes is lower than in wild-type leukocytes and persists through 16 to 30 minutes but not after 30 minutes when mice exhibit an increase in the flux fraction
• following surgical trauma, rolling velocity at 0 to 15 minutes is increased compared to in wild-type leukocytes then decreases to normal after 15 minutes
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