Phenotypes Associated with This Genotype

Genotype
MGI:3784691

• Allelic Composition: Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}/0
• Genetic Background: B6.Cg-Zbtb20^{Tg(PDGFB-APPSwInd)20Lms}

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired long-term object recognition memory ( J:331150 )

• during the choice phase of the novel object recognition test, mice spend a similar amount of time exploring novel and old objects, indicating recognition memory deficits

nervous system

amyloid beta deposits ( J:100954 )

• mice develop amyloid peptide deposits by 5-7 months of age

abnormal cerebral cortex pyramidal cell morphology ( J:118589 )

• at 6 months and 12 to 16 months of age, 30% fewer pyramidal cells in the entorhinal cortex express Reelin than in wild-type mice

• however, no neuron loss is observed

abnormal neurite morphology ( J:100954 )

• dystrophic neurites are associated with plaques

homeostasis/metabolism

amyloid beta deposits ( J:100954 )

• mice develop amyloid peptide deposits by 5-7 months of age