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Phenotypes Associated with This Genotype
Genotype
MGI:3784690
Allelic
Composition
Lystbg-Lac/Lystbg-Lac
Genetic
Background
CBA/CaLac-Lystbg-Lac
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Lystbg-Lac mutation (0 available); any Lyst mutation (117 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
hematopoietic system
• no evidence of NK cells is observed

immune system
• no evidence of NK cells is observed

cellular
• large granules like those associated with Chediak-Higashi Syndrome are observed

craniofacial
• pigmentation is reduced, much lighter than normal

hearing/vestibular/ear
• pigmentation is reduced, much lighter than normal

limbs/digits/tail
• pigmentation is reduced, appearing much lighter than normal

pigmentation
• pigmentation is reduced, much lighter than normal
• the coat appears grey on this background
• pigmentation is reduced, appearing much lighter than normal
• eyes are light at birth, varying from ruby to almost black in adults

vision/eye
• eyes are light at birth, varying from ruby to almost black in adults

integument
• pigmentation is reduced, much lighter than normal
• the coat appears grey on this background
• pigmentation is reduced, appearing much lighter than normal

growth/size/body
• pigmentation is reduced, much lighter than normal

Mouse Models of Human Disease
OMIM ID Ref(s)
Chediak-Higashi Syndrome; CHS 214500 J:29745


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
11/29/2016
MGI 6.06
The Jackson Laboratory