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Phenotypes Associated with This Genotype
Genotype
MGI:3784504
Allelic
Composition
Ppargtm3(tTA)Yba/Pparg+
Genetic
Background
involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm3(tTA)Yba mutation (1 available); any Pparg mutation (22 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mild lipodystrophy with modest metabolic anomalies in Ppargtm3(tTA)Yba/Pparg+ mice compared to Ppargtm2(tTA)Yba/Pparg+ mice

adipose tissue
• subcutaneous fat pad is reduced but present
• however, treatment with doxycycline reverses defects observed
• brown adipocytes are pale, unilocular and hypertrophic
• however, no buffalo humps are observed and treatment wit doxycycline reverses defects observed
• authors state that defects in brown adipose tissue are the same as in Ppargtm2Yba heterozygotes
• brown adipocytes are pale, unilocular and hypertrophic
• however, treatment with doxycycline reverses defects observed
• brown adipocytes are hypertrophic
• gonadal fat pads are reduced compared to in wild-type mice
• however, treatment with doxycycline reverses defects observed

homeostasis/metabolism
• however, treatment with doxycycline reverses defects observed
• insulin levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes
• triglyceride levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes
• however, treatment with doxycycline reverses defects observed

liver/biliary system
• the liver is modestly increased in size compared to in wild-type mice
• however, treatment with doxycycline reverses defects observed

integument
• subcutaneous fat pad is reduced but present
• however, treatment with doxycycline reverses defects observed


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
09/20/2016
MGI 6.05
The Jackson Laboratory