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Phenotypes Associated with This Genotype
Genotype
MGI:3784504
Allelic
Composition
Ppargtm3(tTA)Yba/Pparg+
Genetic
Background
involves: 129S1/SvImJ * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ppargtm3(tTA)Yba mutation (1 available); any Pparg mutation (16 available)
phenotype observed in females
phenotype observed in males
N normal phenotype

Mild lipodystrophy with modest metabolic anomalies in Ppargtm3(tTA)Yba/Pparg+ mice compared to Ppargtm2(tTA)Yba/Pparg+ mice

adipose tissue
• subcutaneous fat pad is reduced but present (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• subcutaneous fat pad is reduced but present (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• brown adipocytes are pale, unilocular and hypertrophic (J:125992)
• however, no buffalo humps are observed and treatment wit doxycycline reverses defects observed (J:125992)
• authors state that defects in brown adipose tissue are the same as in Ppargtm2Yba heterozygotes (J:125992)
• brown adipocytes are pale, unilocular and hypertrophic (J:125992)
• however, no buffalo humps are observed and treatment wit doxycycline reverses defects observed (J:125992)
• authors state that defects in brown adipose tissue are the same as in Ppargtm2Yba heterozygotes (J:125992)
• brown adipocytes are pale, unilocular and hypertrophic (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• brown adipocytes are pale, unilocular and hypertrophic (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• brown adipocytes are hypertrophic (J:125992)
• brown adipocytes are hypertrophic (J:125992)
• gonadal fat pads are reduced compared to in wild-type mice (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• gonadal fat pads are reduced compared to in wild-type mice (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)

homeostasis/metabolism
• however, treatment with doxycycline reverses defects observed (J:125992)
• insulin levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• insulin levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes (J:125992)
• triglyceride levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• triglyceride levels are elevated compared to those in wild-type mice but not as high as in Ppargtm2Yba heterozygotes (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)

liver/biliary system
• the liver is modestly increased in size compared to in wild-type mice (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• the liver is modestly increased in size compared to in wild-type mice (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)

integument
• subcutaneous fat pad is reduced but present (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)
• subcutaneous fat pad is reduced but present (J:125992)
• however, treatment with doxycycline reverses defects observed (J:125992)


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Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Tumor Biology (MTB), Gene Ontology (GO), MouseCyc
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last database update
02/02/2016
MGI 6.02
The Jackson Laboratory