Phenotypes Associated with This Genotype

Genotype
MGI:3784466

• Allelic Composition: 1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}/0
• Genetic Background: C.FVB-1700016L21Rik^{Tg(Itgax-HBEGF/EGFP)57Lan}/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

immune system phenotype ( J:96123 )

N • conventional T cell, macrophages, B cell, NK cell, and NK T cell numbers are unaffected by treatment with diphtheria toxin

decreased dendritic cell number ( J:96123 )

• 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells

abnormal NK cell physiology ( J:96123 )

• following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin

decreased circulating interferon-gamma level ( J:96123 )

• following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin

decreased circulating interleukin-12 level ( J:96123 )

• following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin

decreased interferon-gamma secretion ( J:96123 )

• following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin

homeostasis/metabolism

decreased circulating interferon-gamma level ( J:96123 )

• following treatment with diphtheria toxin, little IFN-gamma in alpha-GalCer-injected mice and no IFN-gamma in alpha-C-GalCer-injected mice was detected unlike in transgenic mice not treated with diphtheria toxin

decreased circulating interleukin-12 level ( J:96123 )

• following treatment with diphtheria toxin and stimulation with alpha-GalCer or alpha-C-GalCer, virtually no serum IL-12 was detected unlike in transgenic mice not treated with diphtheria toxin

hematopoietic system

decreased dendritic cell number ( J:96123 )

• 24 hours after treatment with diphtheria toxin, spleens and livers are depleted of dendritic cells

abnormal NK cell physiology ( J:96123 )

• following treatment with diphtheria toxin and stimulation with alpha-GalCer, only 2% at 6 hours and 4% at 12 hours post-treatment of liver or spleen NK cells stain positive for IFN-gamma compared to 20% to 23% and 13% to 16%, respectively, of cells from transgenic mice not treated with diphtheria toxin