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Phenotypes Associated with This Genotype
Genotype
MGI:3784424
Allelic
Composition		 C3tm1Crr/C3tm1Crr
Tg(Ins2-TFRC/OVA)296Wehi/0
Genetic
Background		 involves: 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
C3tm1Crr mutation (3 available); any C3 mutation (102 available)
Tg(Ins2-TFRC/OVA)296Wehi mutation (1 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
mortality/aging ( J:122114 )
N
• mice injected with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG survive unlike of similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

immune system
increased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
insulitis ( J:122114 )
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse alone exhibit higher a incidence of insulitis than of similarly treated Tg(Ins2-TFRC/OVA)296Wehi and Tg(Ins2-TFRC/OVA)296Wehi Fcer1gtm1Rav/Fcer1gtm1Rav mice
increased interferon-gamma secretion ( J:122114 )
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse without anti-ovalbumin IgG exhibit an IFN-gamma production that is increased 3-fold compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
decreased susceptibility to autoimmune diabetes ( J:122114 )
• only 40% of mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse and anti-ovalbumin IgG exhibit diabetes compared to 100% of similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice
• the severity of diabetes induced by Tg(TcraTcrb)1100Mjb CD8+ T cells and anti-ovalbumin IgG is reduced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

endocrine/exocrine glands
insulitis ( J:122114 )
• mice treated with Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse alone exhibit higher a incidence of insulitis than of similarly treated Tg(Ins2-TFRC/OVA)296Wehi and Tg(Ins2-TFRC/OVA)296Wehi Fcer1gtm1Rav/Fcer1gtm1Rav mice

hematopoietic system
increased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

cellular
increased T cell proliferation ( J:122114 )
• proliferation of Tg(TcraTcrb)1100Mjb CD8+ T cells from a Rag1 null mouse in the presence or absence of anti-ovalbumin IgG is enhanced compared to in similarly treated Tg(Ins2-TFRC/OVA)296Wehi mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/30/2024
MGI 6.23 		The Jackson Laboratory