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Phenotypes Associated with This Genotype
Genotype
MGI:3784391
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(Eno2-APP*751)10Cord/0
Genetic
Background		 involves: 129P2/OlaHsd * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (33 available); any Apoe mutation (145 available)
Tg(Eno2-APP*751)10Cord mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased cerebral infarct size ( J:133156 )
• compared to in Apoetm1Unc homozygotes, Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc

nervous system
increased cerebral infarct size ( J:133156 )
• compared to in Apoetm1Unc homozygotes, Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc
gliosis ( J:133156 )
• mice exhibit more severe microgliosis following middle cerebral artery occlusion compared to Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE_i4)1Hol Apoetm1Unc/Apoetm1Unc mice and Tg(Eno2-APP*751)10Cord Tg(GFAP-APOE*4)1Hol Apoetm1Unc/Apoetm1Unc mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
04/16/2024
MGI 6.23 		The Jackson Laboratory