Phenotypes Associated with This Genotype

Genotype
MGI:3784385

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(APPV717F)109Ili/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:127846 , J:133058 )

• 40% of mice exhibit plaque depositions at 12 months of age with one mouse remaining plaque free at 21 months (J:127846)

• 23% of mice at 15 months, 33% at 18 months and 55% at 21 months exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus (J:127846)

• 3 of 4 mice exhibit plaques by 12 months of age (J:133058)

homeostasis/metabolism

amyloid beta deposits ( J:127846 , J:133058 )

• 40% of mice exhibit plaque depositions at 12 months of age with one mouse remaining plaque free at 21 months (J:127846)

• 23% of mice at 15 months, 33% at 18 months and 55% at 21 months exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)

• mice exhibit plaques in the stratum oriens and radiatum of the hippocampus and hilus of the dentate gyrus (J:127846)

• 3 of 4 mice exhibit plaques by 12 months of age (J:133058)