Phenotypes Associated with This Genotype

Genotype
MGI:3784383

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(APPV717F)109Ili/0; Tg(GFAP-APOE_i4)#Hol/0
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:127846 , J:133058 )

• by 15 to 18 months, 60% of mice exhibit plaques in the hippocampus (J:127846)

• the amount of amyloid deposited is more than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc mice but much less than in Tg(APPV717F)109Ili Apoe^tm1Unc/Apoe^tm1Unc mice (J:127846)

• plaques are observed in the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)

• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)

• 55.6% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)

• mice exhibit increased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc mice (J:133058)

• 44% of mice exhibit thioflavine-S+ amyloid staining (fibrillar amyloid) in the molecular layer unlike in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc and Tg(APPV717F)109Ili Apoe^tm1Unc/Apoe^tm1Unc mice (J:133058)

homeostasis/metabolism

amyloid beta deposits ( J:127846 , J:133058 )

• by 15 to 18 months, 60% of mice exhibit plaques in the hippocampus (J:127846)

• the amount of amyloid deposited is more than in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc mice but much less than in Tg(APPV717F)109Ili Apoe^tm1Unc/Apoe^tm1Unc mice (J:127846)

• plaques are observed in the outer molecular layer of the dentate gyrus and the stratum oriens and radiatum of the hippocampus (J:127846)

• mice exhibit fibrillar plaques in the outer molecular layer of the dentate gyrus (J:127846)

• 55.6% of mice exposed to traumatic brain injury (TBI) at 9 to 10 months of age exhibit amyloid plaques by 12 to 13 months of age while mice not exposed to TBI do not exhibit plaques until 15 months of age (J:133058)

• mice exhibit increased plaque formation and severity following TBI compared to in similarly treated Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc mice (J:133058)

• 44% of mice exhibit thioflavine-S+ amyloid staining (fibrillar amyloid) in the molecular layer unlike in Tg(APPV717F)109Ili Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/Apoe^tm1Unc and Tg(APPV717F)109Ili Apoe^tm1Unc/Apoe^tm1Unc mice (J:133058)