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Phenotypes Associated with This Genotype
Genotype
MGI:3784306
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Tg(GFAP-APOE_i4)22Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Tg(GFAP-APOE_i4)22Hol
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Tg(GFAP-APOE_i4)22Hol mutation (0 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is slower than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons
• in vitro, neurite length is shorter than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons

cellular
abnormal axon extension ( J:93487 )
• in vitro, neuron outgrowth is slower than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons
• in vitro, neurite length is shorter than in Tg(GFAP-APOE_i3)37Hol Apoetm1Unc/Apoetm1Unc neurons

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/18/2025
MGI 6.24 		The Jackson Laboratory