Phenotypes Associated with This Genotype

Genotype
MGI:3784303

• Allelic Composition: Apoe^tm1Unc/Apoe^tm1Unc; Tg(GFAP-APOE_i3)37Hol/0
• Genetic Background: B6.Cg-Tg(GFAP-APOE_i3)37Hol Apoe^tm1Unc/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:93487 )

• in vitro, neuron outgrowth is faster than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

• in vitro, neurite length is longer than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

• however, neurite outgrowth rate is equivalent to in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG

abnormal astrocyte physiology ( J:58019 )

• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoe^tm1Unc homozygotes

cellular

abnormal axon extension ( J:93487 )

• in vitro, neuron outgrowth is faster than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

• in vitro, neurite length is longer than in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons

• however, neurite outgrowth rate is equivalent to in Apoe^tm1Unc/Apoe^tm1Unc Tg(GFAP-APOE_i4)22Hol neurons when neurons are treated with RAP or anti-LRP IgG

abnormal astrocyte physiology ( J:58019 )

• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoe^tm1Unc homozygotes