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Phenotypes Associated with This Genotype
Genotype
MGI:3784302
Allelic
Composition		 Apoetm1Unc/Apoetm1Unc
Cdh18Tg(GFAP-APOE_i4)1Hol/0
Genetic
Background		 B6.Cg-Apoetm1Unc Cdh18Tg(GFAP-APOE_i4)1Hol/J
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Apoetm1Unc mutation (34 available); any Apoe mutation (163 available)
Cdh18Tg(GFAP-APOE_i4)1Hol mutation (1 available); any Cdh18 mutation (56 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
nervous system
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

cellular
abnormal astrocyte physiology ( J:58019 )
• the ratio of lipid to Apoe in HDL particles secreted from astrocytes is lower than in wild-type astrocytes but higher than in Apoetm1Unc homozygotes

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory