Phenotypes Associated with This Genotype

Genotype
MGI:3783888

• Allelic Composition: Apoa1^tm1Bres/Apoa1^tm1Bres
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice

decreased circulating cholesterol level ( J:40819 )

• mice exhibit a 72% reduced in plasma cholesterol level compared to in wild-type mice

• when fed a Western-type diet, mice exhibit a 73% reduced in plasma cholesterol level compared to in wild-type mice

• mice exhibit a 1.9-fold and 2.2-fold decrease in free cholesterol and cholesteryl ester content, respectively, compared to in wild-type mice

decreased circulating HDL cholesterol level ( J:40819 )

• mice exhibit a 74% decrease in HDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 83% decrease in HDL-C levels compared to wild-type mice

decreased circulating LDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

decreased circulating VLDL cholesterol level ( J:40819 )

• mice exhibit a 62% decrease in VLDL-C and LDL-C levels compared to wild-type mice

• when fed a Western-type diet, mice exhibit a 42% decrease in VLDL-C and LDL-C levels compared to wild-type mice

increased circulating triglyceride level ( J:40819 )

• mice exhibit an 8-fold decrease in triglycerides compared to wild-type mice

cellular

decreased cholesterol efflux ( J:40819 )

• HDL cholesteryl ester transport is decreased 86% and 83%, respectively, when mice are fed a normal or Western-type diet compared to wild-type mice