About   Help   FAQ
Phenotypes Associated with This Genotype
Genotype
MGI:3783879
Allelic
Composition		 Gt(ROSA)26Sortm1(DTA)Mrc/Gt(ROSA)26Sor+
Myf6tm1(cre)Mrc/Myf6+
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(DTA)Mrc mutation (1 available); any Gt(ROSA)26Sor mutation (944 available)
Myf6tm1(cre)Mrc mutation (0 available); any Myf6 mutation (19 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
mortality/aging
neonatal lethality, complete penetrance ( J:133338 )
• pups are immobile and die shortly after birth

muscle
abnormal myogenesis ( J:133338 )
• myogenesis appears normal at E12.5
• increasing apoptosis until all differentiating myofibers are either dead or dying at E18.5
abnormal skeletal muscle fiber morphology ( J:133338 )
• newborns lack differentiated myofibers
• basophilic clumps of cellular debris suggest skeletal muscle forms and then degenerates

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support. 		last database update
05/07/2024
MGI 6.23 		The Jackson Laboratory