Phenotypes Associated with This Genotype

Genotype
MGI:3783849

• Allelic Composition: Tg(Cryaa-AKR1B1)648Smch/0
• Genetic Background: involves: C57BL * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

cataract ( J:106642 )

• mice injected with streptozotocin are susceptible to diabetic cataract formation, but cataracts do not develop as rapidly as in galactosemic transgenic mice

homeostasis/metabolism

abnormal homeostasis ( J:106642 )

• mice injected with streptozotocin exhibit higher accumulation of sorbitol in the lens than wild-type beginning at 1 week after diabetes development