Phenotypes Associated with This Genotype

Genotype
MGI:3783755

• Allelic Composition: Lse/Lse
• Genetic Background: B6C3Fe a/a-Lse/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

perinatal lethality ( J:338204 )

prenatal lethality, incomplete penetrance ( J:8618 )

• homozygotes either die in utero or have the same phenotype as heterozygotes

craniofacial

craniofacial phenotype ( J:338204 )

N • no obvious suture defects

cleft secondary palate ( J:338204 )

• at E17.5 and E18.5

lowered ear position ( J:338204 )

• visible at E13.5 and E17.5

abnormal outer ear development ( J:338204 )

• reduced outer ear development at E17.5

hearing/vestibular/ear

lowered ear position ( J:338204 )

• visible at E13.5 and E17.5

abnormal outer ear development ( J:338204 )

• reduced outer ear development at E17.5

decreased tympanic ring size ( J:338204 )

• extremely hypomorphic and anteriorly shifted at E18.5

vision/eye

exophthalmos ( J:338204 )

limbs/digits/tail

postaxial polydactyly ( J:338204 )

• forelimb and hindlimb polydactyly

digestive/alimentary system

cleft secondary palate ( J:338204 )

• at E17.5 and E18.5

growth/size/body

cleft secondary palate ( J:338204 )

• at E17.5 and E18.5

lowered ear position ( J:338204 )

• visible at E13.5 and E17.5

abnormal outer ear development ( J:338204 )

• reduced outer ear development at E17.5