Phenotypes Associated with This Genotype

Genotype
MGI:3783733

• Allelic Composition: Socs3^tm1Jni/Socs3⁺
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased susceptibility to diet-induced obesity ( J:91797 )

decreased circulating leptin level ( J:91797 )

• when placed on a high fat diet mice do not exhibit an increase in leptin levels compared to wild-type mice

growth/size/body

weight loss ( J:91797 )

• unlike wild-type mice, treatment with leptin results in weight loss despite equivalent leptin serum levels

decreased susceptibility to diet-induced obesity ( J:91797 )

adipose tissue

decreased total body fat amount ( J:91797 )

• when treated with leptin