Phenotypes Associated with This Genotype

Genotype
MGI:3783650

• Allelic Composition: Adamts20^bt-2H/Adamts20^bt-2H; Tg(Dct-lacZ)A12Jkn/0
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

pigmentation phenotype ( J:133403 )

N • despite white spotting, melanoblast initial specification and migration are normal

belted ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

white spotting ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

embryo

abnormal melanoblast migration ( J:133403 )

• as early as E13.5, melanoblasts fail to distribute uniformly across dorsal and lateral surfaces of the trunk unlike in wild-type mice

• however, head distribution of melanoblasts is normal and the relative distribution through out the skin layers is normal

• melanoblasts are lacking in areas corresponding to the future belt as early as E15.5 and E16.5

• while melanoblast proliferation is normal, melanoblast survival is reduced compared to in wild-type mice

• unlike in wild-type mice, there is no difference in the melanoblast number between the head and trunk

• apoptosis of melanoblasts is increased 7-fold in the head and to a lesser extent in the trunk compared to in wild-type mice

• fewer melanoblasts survive and migrate into the hair follicle than in wild-type mice

integument

belted ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

white spotting ( J:133403 )

• mice exhibit white spotting on the dorsal and ventral surfaces at the lumbar level that appear as a belt

cellular

abnormal melanoblast migration ( J:133403 )

• as early as E13.5, melanoblasts fail to distribute uniformly across dorsal and lateral surfaces of the trunk unlike in wild-type mice

• however, head distribution of melanoblasts is normal and the relative distribution through out the skin layers is normal

• melanoblasts are lacking in areas corresponding to the future belt as early as E15.5 and E16.5

• while melanoblast proliferation is normal, melanoblast survival is reduced compared to in wild-type mice

• unlike in wild-type mice, there is no difference in the melanoblast number between the head and trunk

• apoptosis of melanoblasts is increased 7-fold in the head and to a lesser extent in the trunk compared to in wild-type mice

• fewer melanoblasts survive and migrate into the hair follicle than in wild-type mice