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Phenotypes Associated with This Genotype
Genotype
MGI:3783643
Allelic
Composition		 Gt(ROSA)26Sortm1(Tfrc*)Nca/Gt(ROSA)26Sor+
Hfetm2Nca/Hfetm2Nca
Genetic
Background		 involves: 129S4/SvJae * 129S6/SvEvTac * FVB/N
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gt(ROSA)26Sortm1(Tfrc*)Nca mutation (1 available); any Gt(ROSA)26Sor mutation (1098 available)
Hfetm2Nca mutation (1 available); any Hfe mutation (35 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
homeostasis/metabolism
increased circulating iron level ( J:133221 )
• significant increase in occupancy of serum transferrin with iron
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal

liver/biliary system
increased liver iron level ( J:133221 )
• increase in liver non-heme iron levels
• this increase is intermediate between that of mice homozygous for Hfetm2Nca or Gt(ROSA)26Sortm1(Tfrc*)Nca alone
• deposition of iron is predominantly periportal

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory