Phenotypes Associated with This Genotype

Genotype
MGI:3783548

• Allelic Composition: Apaf1^tm1Mak/Apaf1^tm1Mak
• Genetic Background: involves: 129P2/OlaHsd * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:131954 )

N • at E13-14 and E18, numbers of spinal motoneurons and dorsal root ganglion neurons are not different from wild-type

exencephaly ( J:131954 )

• forebrain exencephaly is observed in all animals

abnormal neuron morphology ( J:131954 )

• at E14 and E18, motoneurons and DRG neurons exhibit degenerative-like changes not seen in wild-type

abnormal neuron physiology ( J:131954 )

• at E14, developing neurons undergo atypical programmed cell death (PCD) in contrast to type 1 (apoptotic-like) mechanism exhibited in wild-type neurons; apoptotic-like degeneration markers (such as TUNEL labeling) are not observed in dying mutant neurons