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Phenotypes Associated with This Genotype
Genotype
MGI:3783541
Allelic
Composition		 Cops5tm1Rpar/Cops5tm1Rpar
Tg(Lck-cre)548Jxm/0
Tg(TcraTcrb)425Cbn/0
Genetic
Background		 involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Cops5tm1Rpar mutation (0 available); any Cops5 mutation (26 available)
Tg(Lck-cre)548Jxm mutation (2 available)
Tg(TcraTcrb)425Cbn mutation (7 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
hematopoietic system
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control

immune system
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control

endocrine/exocrine glands
decreased thymocyte number ( J:132114 )
• an 80-90% reduction compared to control

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory