Phenotypes Associated with This Genotype

Genotype
MGI:3783540

• Allelic Composition: Cops5^tm1Rpar/Cops5^tm1Rpar; Tg(Lck-cre)548Jxm/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * CBA * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

hematopoietic system

increased T cell apoptosis ( J:132114 )

• in DN and DP thymocytes

thymus medulla hypoplasia ( J:132114 )

• a severely hypoplastic medulla

decreased thymocyte number ( J:132114 )

• an 80-90% reduction

decreased double-positive T cell number ( J:132114 )

• a marked decrease in the proportion of DP and SP thymocytes

• DN thymocytes percentage and absolute numbers were not significantly altered

decreased single-positive T cell number ( J:132114 )

• a marked decrease in the proportion of DP and SP thymocytes

immune system

increased T cell apoptosis ( J:132114 )

• in DN and DP thymocytes

thymus medulla hypoplasia ( J:132114 )

• a severely hypoplastic medulla

decreased thymocyte number ( J:132114 )

• an 80-90% reduction

decreased double-positive T cell number ( J:132114 )

• a marked decrease in the proportion of DP and SP thymocytes

• DN thymocytes percentage and absolute numbers were not significantly altered

decreased single-positive T cell number ( J:132114 )

• a marked decrease in the proportion of DP and SP thymocytes

cellular

abnormal cell cycle checkpoint function ( J:132114 )

• cell cycle arrest at S/G2/M phase in DN thymocyte

increased T cell apoptosis ( J:132114 )

• in DN and DP thymocytes

endocrine/exocrine glands

thymus medulla hypoplasia ( J:132114 )

• a severely hypoplastic medulla

decreased thymocyte number ( J:132114 )

• an 80-90% reduction