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Phenotypes Associated with This Genotype
Genotype
MGI:3783422
Allelic
Composition		 Aqp1tm1Ask/Aqp1tm1Ask
Aqp4tm1Ask/Aqp4tm1Ask
Genetic
Background		 involves: C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp1tm1Ask mutation (0 available); any Aqp1 mutation (27 available)
Aqp4tm1Ask mutation (0 available); any Aqp4 mutation (45 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
growth/size/body
postnatal growth retardation ( J:106259 )
• mice grow 15-20% slower than wild-type animals

respiratory system
abnormal respiratory system physiology ( J:106259 )
• lower rate of water transport in lungs relative to Aqp1-null animals is measured

cardiovascular system
decreased vascular permeability ( J:106259 )
• airspace-capillary water permeability in lungs is reduced compared to Aqp1-null mice
• water permeability is 15-fold lower than in wild-type lungs

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/13/2026
MGI 6.24 		The Jackson Laboratory