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Phenotypes Associated with This Genotype
Genotype
MGI:3783406
Allelic
Composition		 Aqp1tm1Ask/Aqp1tm1Ask
Aqp5tm1Ask/Aqp5tm1Ask
Genetic
Background		 involves: C57BL/6J * CD-1
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Aqp1tm1Ask mutation (0 available); any Aqp1 mutation (27 available)
Aqp5tm1Ask mutation (0 available); any Aqp5 mutation (21 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
respiratory system
abnormal respiratory system physiology ( J:106285 )
• small (4-7%), significant reduction in lower airway humidification relative to wild-type
• 3-9% impairment of upper airway humidification compared to controls

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
01/28/2026
MGI 6.24 		The Jackson Laboratory