Phenotypes Associated with This Genotype

Genotype
MGI:3783341

• Allelic Composition: Ret^tm1Heno/Ret^tm1Heno
• Genetic Background: Not Specified

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

abnormal motor neuron innervation pattern ( J:132854 )

• peroneal muscles totally lack both motor and sensory innervation in 42% of homozygotes

• 58% with normal peroneal innervation or with innervation absent only in the superficial peroneal muscles

decreased motor neuron number ( J:132854 )

• elevated apoptosis of motor neurons between 13.5 and E15.5

muscle

abnormal hypaxial muscle morphology ( J:132854 )

abnormal gastrocnemius morphology ( J:132854 )

• reduced in size but with normal motor innervation

abnormal muscle spindle morphology ( J:132854 )

• reduced fusimotor innervation of muscle spindles

• muscle spindle innervation normal in Rectus femoris

limbs/digits/tail

abnormal gastrocnemius morphology ( J:132854 )

• reduced in size but with normal motor innervation