Phenotypes Associated with This Genotype

Genotype
MGI:3783332

• Allelic Composition: Tpsb2^tm1.1Mfg/Tpsb2^tm1.1Mfg
• Genetic Background: B6.129-Tpsb2^tm1.1Mfg

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

abnormal mast cell differentiation ( J:142880 )

• synovial mast cells do not express the mMcp-6 protease

impaired neutrophil chemotaxis ( J:142880 )

• the number of neutrophils in arthritic synovial tissue is one-third that of C57BL/6 controls

impaired eosinophil recruitment ( J:133373 )

• there is almost a two-fold reduction in the number of eosinophils recruited to sites of T. spiralis infection in tongue skeletal muscle

decreased susceptibility to induced arthritis ( J:142880 )

• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls

• ankle thickness is also less than controls 10 days after arthritis induction

• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced

increased susceptibility to parasitic infection ( J:133373 )

• mice chronically infected with T. spiralis have significantly higher live worm burden and significantly less percentage of necrotic worm larvae in their tongue skeletal muscle

cellular

abnormal mast cell differentiation ( J:142880 )

• synovial mast cells do not express the mMcp-6 protease

impaired neutrophil chemotaxis ( J:142880 )

• the number of neutrophils in arthritic synovial tissue is one-third that of C57BL/6 controls

hematopoietic system

abnormal mast cell differentiation ( J:142880 )

• synovial mast cells do not express the mMcp-6 protease

impaired neutrophil chemotaxis ( J:142880 )

• the number of neutrophils in arthritic synovial tissue is one-third that of C57BL/6 controls

impaired eosinophil recruitment ( J:133373 )

• there is almost a two-fold reduction in the number of eosinophils recruited to sites of T. spiralis infection in tongue skeletal muscle

skeleton

decreased susceptibility to induced arthritis ( J:142880 )

• there is a signifcant decrease in clinical measurements of joint inflammation induced by Tg(TcraR28,TcrbR28)KRNDim (i.e. K/BxN) mouse serum compared to C57BL/6 controls

• ankle thickness is also less than controls 10 days after arthritis induction

• histological scores of bone and cartilage erosion, as well as inflammation, are also significantly reduced