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Phenotypes Associated with This Genotype
Genotype
MGI:3779041
Allelic
Composition		 Ggta1tm1Jbl/Ggta1+
Ightm1Jiac/Ightm1Jiac
Igktm1Jiac/Igk+
Genetic
Background		 involves: 129S2/SvPas * 129S4/SvJae * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Ggta1tm1Jbl mutation (2 available); any Ggta1 mutation (83 available)
Ightm1Jiac mutation (0 available); any Igh mutation (41 available)
Igktm1Jiac mutation (0 available); any Igk mutation (28 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele

hematopoietic system
decreased mature B cell number ( J:133032 )
• the frequency of B220+ B cells in the periphery is 18.7% compared to 24.7% in mice with just one Igh knock-in allele

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
03/25/2025
MGI 6.24 		The Jackson Laboratory