Phenotypes Associated with This Genotype

Genotype
MGI:3779030

• Allelic Composition: Mycbp2^mgln/Mycbp2^mgln; Tg(Isl1-EGFP*)1Slp/0
• Genetic Background: B6.Cg-Mycbp2^mgln Tg(Isl1-EGFP*)1Slp

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

abnormal axon extension ( J:132726 )

• growth cones fail to exhibit the normal phases of outgrowth

abnormal motor neuron morphology ( J:132726 )

• the intercostals motor nerves are reduced in thickness compared to in wild-type mice likely due to reduced numbers of axons present at the nerve

abnormal motor neuron innervation pattern ( J:132726 )

• all mice exhibit severe projection errors in the ventral root with highly fluorescent GFP puncta at the thoracic and lumbar levels of the spinal cord

• mice exhibit limb innervation defects

• branchial motor neuron axons misproject from the ventral root and inappropriately enter the dorsal root ganglion

• lumbar motor neuron axons wander or stall within 100 um of exiting the spinal cord

• upper thoracic motor neuron axons exhibit stalling and misprojection

abnormal sensory neuron morphology ( J:132726 )

• sensory neurons are thinner than in wild-type mice

abnormal sensory neuron innervation pattern ( J:132726 )

• sensory neuron axons are overgrown and defasciculated resulting in thinner nerves at more distal locations compared to in wild-type mice

abnormal spinal nerve morphology ( J:132726 )

• the ventral ramus at the thoracic level is reduced in size while the posterior ramus is more prominent

cellular

abnormal axon extension ( J:132726 )

• growth cones fail to exhibit the normal phases of outgrowth