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Phenotypes Associated with This Genotype
Genotype
MGI:3778393
Allelic
Composition
Tg(DRD1-ctxA)7Burt/0
Genetic
Background
C.Cg-Tg(DRD1-ctxA)7Burt
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(DRD1-ctxA)7Burt mutation (1 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
behavior/neurological
N
• mice display normal olfactory discrimination
• low-doses of MK-801 (non-competitive NMDA receptor antagonist) aggravate the repetitive climbing and leaping behavior of transgenic mice (J:64883)
• mice engage in obsessive-compulsive disorder-like behavior such as prolonged episodes of essentially normal behaviors; total behavior repertoire and average number of behaviors is similar to wild-type (J:133401)
• in light-dark assay, mice display longer latency to first transit from dark chamber and show tendency to spend less time in lighted (reduced transits) areas than controls
• mice exhibit increased thigmotaxis in an open-field assay, compared to non-transgenic littermates
• repetitive twitches (tics) occur at 5-fold higher frequency compared to controls which show twitches infrequently with tics a greater increased frequency observed in females
• tic complexity is increased compared to controls with a higher percentage of non-shaking tics observed; this is statistically significant in females and approaches significance in males relative to control
• occurrence of tic flurries is highly increased in males compared to controls and to a lesser but significant extent in females
• tics are significantly increased in juvenile transgenic animals and adult animals compared to controls
• clonidine (non-cataleptic drug) treatment reduces incidence of tics without affecting locomotor behavior similar to its effects in humans with Tourette's + obsessive compulsive disorder
• at high doses of MK-801, transgenic mice engage in more severe stereotypic/seizure behavior ( such as 'popping') (J:64883)
• treatment with an AMPA receptor antagonist attenuates MK-801-induced stereotypic behaviors, but does not alter transgene-induced (repetitive climbing/leaping) behavior (J:64883)
• upon injection with yohimbine, transgenic animals display a significant increase abnormal repetitive leaping/climbing behavior compared to saline-injected control transgenics, but duration of perseverative (prolonged) episodes is not exacerbated (J:133401)
• mice display compulsion-like behaviors including prolonged behavior such as eating and repetitive behavior like leaping (J:133402)
• presence of a novel odor or a familiar odor in the cage does not potentiate abnormal repetitive leaping-climbing behavior compared to controls (J:133402)
• presence of an anxiogenic odor in the cage increases incidence of leaping-climbing 2-fold relative to controls; anxiogenic odor potentiates compulsion-like behavior (J:133402)

Mouse Models of Human Disease
DO ID OMIM ID(s) Ref(s)
Gilles de la Tourette syndrome DOID:11119 OMIM:137580
J:133268 , J:133402


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
10/08/2019
MGI 6.14
The Jackson Laboratory