Phenotypes Associated with This Genotype

Genotype
MGI:3778392

• Allelic Composition: Lrp5^{Gt(OST164883)Lex}/Lrp5^{Gt(OST164883)Lex}
• Genetic Background: involves: 129S5/SvEvBrd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

skeleton

abnormal long bone diaphysis morphology ( J:133196 )

• cortical thickness of the femoral diaphysis is decreased 11% compared to in wild-type mice

abnormal lumbar vertebrae morphology ( J:133196 )

• trabecular number and thickness of the lumbar vertebra is reduced compared to in wild-type mice

abnormal bone structure ( J:133196 )

decreased bone mineral density ( J:133196 )

• at 6 weeks of age, total and femoral cancellous and cortical bone density are 14% and 16%, respectively, lower than in wild-type mice

decreased bone mineral density of femur ( J:133196 )

• mice exhibit a 19% decrease in femoral bone density

abnormal trabecular bone morphology ( J:133196 )

• cancellous bone volume is decreased 54% in the distal femur and 38% in the lumbar vertebra compared to in wild-type mice

decreased bone mass ( J:133196 )

• mice exhibit a 30% decrease in femoral cancellous and cortical bone mass

decreased compact bone mass ( J:133196 )

• at 6 weeks of age, total and femoral cortical bone mass is 23% lower than in wild-type mice

decreased trabecular bone mass ( J:133196 )

• at 6 weeks of age, total and femoral cancellous bone mass is 21% lower than in wild-type mice

decreased bone ossification ( J:133196 )

• osteoblast surface is reduced 45% compared to in wild-type mice

• bone formation rates are lower due to a decrease in mineralization surface and mineral apposition rate

decreased bone resorption ( J:133196 )

• osteoclast surface is reduced 24% in lumbar vertebrae compared to in wild-type mice

growth/size/body

decreased body weight ( J:133196 )

• at 20 to 28 weeks of age, mice weigh 9% less than wild-type mice