Phenotypes Associated with This Genotype

Genotype
MGI:3777635

• Allelic Composition: Tg(Ela1-TAg*)79Mjt/0; Tg(MUC1)79.24Gend/0
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased pancreas tumor incidence ( J:64570 )

• mice develop pancreatic tumors that can be grossly visualized at 9 weeks of age

• at 18 and 21 weeks, mice develop large solid tumor masses of less differentiated acinar cell carcinomas

increased pancreas adenoma incidence ( J:64570 )

• pancreas consists of acinar cell microadenomas

increased pancreatic acinar cell carcinoma incidence ( J:64570 )

• pancreas consists of acinar cell carcinomas; well-differentiated acinar cell carcinomas are observed

endocrine/exocrine glands

abnormal pancreas morphology ( J:64570 )

• double transgenic mice exhibit acinar cell dysplasia at birth, which progresses to single or multiple cell acinar cell carcinomas

• increased pancreas weight is general indicator of tumor burden, but in many animals 15 weeks of age or older, pancreas weights do not increase presumably due to cachexia

increased pancreas tumor incidence ( J:64570 )

• mice develop pancreatic tumors that can be grossly visualized at 9 weeks of age

• at 18 and 21 weeks, mice develop large solid tumor masses of less differentiated acinar cell carcinomas

increased pancreas adenoma incidence ( J:64570 )

• pancreas consists of acinar cell microadenomas

increased pancreatic acinar cell carcinoma incidence ( J:64570 )

• pancreas consists of acinar cell carcinomas; well-differentiated acinar cell carcinomas are observed

immune system

immune system phenotype ( J:64570 )

N • nonimmunized mice develop anti-MUC1 cytotoxic T lymphocytes by 12 weeks and show 80% lysis of MUC1-expressing target cells by 18 weeks