Phenotypes Associated with This Genotype

Genotype
MGI:3777350

• Allelic Composition: Tg(Lck-cre)I57Jxm/?; Traf3^tm1Rbr/Traf3^tm1Rbr
• Genetic Background: involves: C57BL/6 * ICR * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased CD4-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD4 T cells in the spleen are slightly reduced

decreased CD8-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD8 T cells in the spleen are slightly reduced

abnormal T cell physiology ( J:132877 )

• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed

hematopoietic system

decreased CD4-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD4 T cells in the spleen are slightly reduced

decreased CD8-positive, alpha-beta T cell number ( J:132877 )

• numbers of CD8 T cells in the spleen are slightly reduced

abnormal T cell physiology ( J:132877 )

• extensive activation of the alternative NF-kappaB pathway occurs though no effect on T cell survival is observed