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Phenotypes Associated with This Genotype
Genotype
MGI:3777349
Allelic
Composition
Tg(Lck-cre)I57Jxm/?
Traf2tm1Rbr/Traf2tm1Rbr
Genetic
Background
involves: C57BL/6 * ICR
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tg(Lck-cre)I57Jxm mutation (5 available)
Traf2tm1Rbr mutation (0 available); any Traf2 mutation (27 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
immune system
• mature B cells are virtually absent from the lymph nodes
• follicular B cells are absent from the spleen
• marginal zone B cells are absent from the spleen

hematopoietic system
• mature B cells are virtually absent from the lymph nodes
• follicular B cells are absent from the spleen
• marginal zone B cells are absent from the spleen


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
01/28/2026
MGI 6.24
The Jackson Laboratory