Phenotypes Associated with This Genotype

Genotype
MGI:3777244

• Allelic Composition: Lfng^tm1Rjo/Lfng^tm1Rjo
• Genetic Background: either: (involves: 129S7/SvEvBrd * C57BL/6J) or (involves: 129S7/SvEvBrd * C57BL/6J * FVB/N)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:131837 )

• survival of homozygotes postnatally is only rarely observed

embryo

abnormal rostral-caudal patterning of the somites ( J:131837 )

• at E9.5, little compartmentalization of somites is observed, with rostral and caudal cells appearing mixed

• at E10.5, somites in thoracic region fail to compartmentalize, maintaining an unsegmented pattern and this continues during secondary body formation

skeleton

rib fusion ( J:131837 )

• in thoracic region, multiple rib fusions are observed

abnormal thoracic vertebrae morphology ( J:131837 )

• thoracic vertebrae are disorganized; vertebral condensations are irregular and misaligned

abnormal lumbar vertebrae morphology ( J:131837 )

• vertebral disorganization extends through lumbar region; vertebral condensations are irregular and misaligned

abnormal sacral vertebrae morphology ( J:131837 )

• vertebral disorganization extends through sacral region; vertebral condensations are irregular and misaligned

limbs/digits/tail

short tail ( J:131837 )

• tail is severely truncated

reproductive system

male infertility ( J:131837 )

♂ • males surviving to adulthood are sterile