Phenotypes Associated with This Genotype

Genotype
MGI:3777243

• Allelic Composition: Lfng^tm1Seco/Lfng^tm1Seco
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

embryo

abnormal somite development ( J:131837 )

• somites contributing to the thoracic and lumbar regions of the skeleton are irregularly sized and spaced with frequent fusions between adjacent somites at E9.5

• at E10.5, mature derivatives of lumbar and thoracic somites remain irregularly spaced

• during secondary body formation, somite development recovers and relatively evenly spaced and sized epithelial somites form

abnormal rostral-caudal patterning of the somites ( J:131837 )

• embryos at E9 somites display a less distinct rostral border at all stages of somitogenesis, compared to wild-type

• anterior somites display compartmentalization, but compartments are irregulary spaced at E9.5

• at E10.5, thoracic region somites display distinct compartmentalization, but compartments are irregularly spaced or shaped

• during secondary body formation, somites are clearly compartmentalized

abnormal somite size ( J:131837 )

• at E10.5, mature derivatives of lumbar and thoracic somites remain irregularly sized

growth/size/body

decreased body length ( J:131837 )

• animals have shortened bodies, indicating segmentation defects

skeleton

rib fusion ( J:131837 )

• in thoracic region, multiple rib fusions are observed

abnormal thoracic vertebrae morphology ( J:131837 )

• thoracic vertebrae display severe disorganization; vertebral condensations are irregular and misaligned

abnormal lumbar vertebrae morphology ( J:131837 )

• vertebral disorganization extends through lumbar region; vertebral condensations are irregular and misaligned

• this phenotype stops at lumbo-sacral junction

limbs/digits/tail

kinked tail ( J:131837 )

• animals display variably kinked tails, demonstrating segmentation defects; 40% of animals display mild defects, while remainder show more moderate abnormalities