Phenotypes Associated with This Genotype

Genotype
MGI:3777106

• Allelic Composition: Tg(PDGFB-APP)5Lms/?
• Genetic Background: involves: C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:62290 )

N • no amyloid plaques are detected by immunohistochemistry up to the age of 24 months

amyloid beta deposits ( J:137264 )

• significantly elevated beta amyloid

• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet

neurodegeneration ( J:62290 )

• neurodegeneration is indicated by an age dependent decrease in density of synaptophysin-immunoreactive presynaptic terminals

homeostasis/metabolism

amyloid beta deposits ( J:137264 )

• significantly elevated beta amyloid

• a further 3 fold increase in amyloid beta 40 but not amyloid beta 42 when placed on a high fat diet