Phenotypes Associated with This Genotype

Genotype
MGI:3777013

• Allelic Composition: Trp53^tm2Att/Trp53^tm2Att
• Genetic Background: either: (involves: 129S4/SvJae) or (involves: 129S4/SvJae * C57BL/6)

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

abnormal cell cycle ( J:131856 )

• cre-transfected MEFs display cell cycle arrest in the absence of DNA damage

decreased cellular sensitivity to ultraviolet irradiation induced cell death ( J:131856 )

• MEFs transfected with adenoviral cre fail to induce apoptosis in response to UVC

early cellular replicative senescence ( J:131856 )

• cre-transfected MEFs display markers of cellular senescence within 4 days of transfection which are not seen in controls (cre-transfected-MEFs homozygous for Trp53^tm5Tyj)