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Phenotypes Associated with This Genotype
Genotype
MGI:3776841
Allelic
Composition
Tcf3tm2Zhu/Tcf3tm2Zhu
Genetic
Background
involves: 129 * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Tcf3tm2Zhu mutation (0 available); any Tcf3 mutation (14 available)
phenotype observed in females
phenotype observed in males
N normal phenotype
mortality/aging
N
• unlike Tcfe2a null mice, survival rates are normal

hematopoietic system
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells
• however, T cell development is normal

reproductive system
N
• unlike Tcfe2a null mice, males and female mice are fertile

immune system
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood
• 10-fold in the bone marrow and 20-fold in the spleen of neonates
• however, B cell numbers recover during adulthood


Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB), Gene Ontology (GO)
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last database update
09/10/2019
MGI 6.14
The Jackson Laboratory