Phenotypes Associated with This Genotype

Genotype
MGI:3776841

• Allelic Composition: Tcf3^tm2Zhu/Tcf3^tm2Zhu
• Genetic Background: involves: 129 * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

mortality/aging ( J:47671 )

N • unlike Tcfe2a null mice, survival rates are normal

hematopoietic system

decreased pro-B cell number ( J:47671 )

• 10-fold in the bone marrow and 20-fold in the spleen of neonates

• however, B cell numbers recover during adulthood

decreased pre-B cell number ( J:47671 )

• 10-fold in the bone marrow and 20-fold in the spleen of neonates

• however, B cell numbers recover during adulthood

abnormal hematopoietic stem cell morphology ( J:47671 )

• hematopoietic stem cells fail to repopulate an irradiated mouse with B cells

• however, T cell development is normal

reproductive system

reproductive system phenotype ( J:47671 )

N • unlike Tcfe2a null mice, males and female mice are fertile

immune system

decreased pro-B cell number ( J:47671 )

• 10-fold in the bone marrow and 20-fold in the spleen of neonates

• however, B cell numbers recover during adulthood

decreased pre-B cell number ( J:47671 )

• 10-fold in the bone marrow and 20-fold in the spleen of neonates

• however, B cell numbers recover during adulthood