Phenotypes Associated with This Genotype

Genotype
MGI:3776790

• Allelic Composition: Hcn4^tm1Rsei/Hcn4^tm1Rsei
• Genetic Background: B6.Cg-Hcn4^tm1Rsei

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:131820 )

• homozygotes develop normally until E11 but are dead by E12

cardiovascular system

decreased cardiac muscle contractility ( J:131820 )

• isolated cardiomyocytes beat more slowly

• slower activation of currents in cardiomyocytes

• faster deactivation of currents in cardiomyocytes

decreased heart rate ( J:131820 )

• embryos display a reduced heart rate between E9.5 and E11.5

• superfusion of either isoproterenol or NKH477 fails to bring about an increase in heart rate

muscle

decreased cardiac muscle contractility ( J:131820 )

• isolated cardiomyocytes beat more slowly

• slower activation of currents in cardiomyocytes

• faster deactivation of currents in cardiomyocytes