Phenotypes Associated with This Genotype

Genotype
MGI:3776630

• Allelic Composition: Tg(Camk2a-tTA)1Mmay/0; Tg(tetO-S100a10)1Pggd/0
• Genetic Background: involves: C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal depression-related behavior ( J:104116 )

• mice exhibit decreased depression-related behavior such as immobility when suspended by their tails

• however, treatment with doxycycline restores normal depression-related behaviors

decreased anxiety-related response ( J:104116 )

• mice exhibit decreased thigmotaxis and increased horizontal activity in an open-field test

• however, treatment with doxycycline restores normal anxiety-related behaviors

hyperactivity ( J:104116 )